A MODIFIED DELPHI APPROACH TO DEVELOP A TRIAL PROTOCOL FOR ANTIBIOTIC DE-ESCALATION IN PATIENTS WITH SUSPECTED SEPSIS

A modified Delphi approach to develop a trial protocol for antibiotic de-escalation in patients with suspected sepsis

Abstract Background: Early administration of antibiotics in sepsis is associated with improved patient outcomes, but safe and generalizable approaches to de-escalate or discontinue antibiotics after suspected sepsis events are unknown.Methods: We used a Nanoblocks modified Delphi approach to identify safety criteria for an opt-out protocol to guide

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Phylogeny of Maleae (Rosaceae) Based on Complete Chloroplast Genomes Supports the Distinction of Aria, Chamaemespilus and Torminalis as Separate Genera, Different from Sorbus sp.

Several genera formerly contained within the genus Sorbus L.sensu lato have been proposed as separate taxa, including Aria, Chamaemespilus and Torminalis.However, molecular evidence for such distinctions are rather scarce.We assembled the complete chloroplast genome of Sorbus aucuparia, another representative of Sorbus s.s., and performed detailed

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